Year: 2024 | 2023 | 2022 | 2021 | 2014-2020 | Book chapters
2024
- Holy EN, Li E, Bhattarai A, Fletcher E, Alfaro ER, Harvey DJ, Spencer BA, Cherry SR, DeCarli CS, Fan AP. "Non-invasive quantification of 18F-florbetaben with total-body EXPLORER PET." Eur J Nucl Med Mol Imag 14 (2024): 39.
Korte JA, Weakley A, Fernandez KD, Joiner WM, Fan AP. Journal of Cognitive Neuroscience 36 (2024): 734-755.
Neural Underpinnings of Learning in Dementia Populations: A Review of Motor Learning Studies Combined with Neuroimaging
Motor learning paradigms can detect changes in various cognitive domains as possible screening techniques for early dementia and understanding aging. When combined with neuroimaging, as reviewed in this paper, we have a powerful platform to understand the neural basis of motor learning and how it changes in AD populations.
2023
- Le LNN, Wheeler GJ, Holy EN, Donnay CA, Blockley NP, Yee AH, Ng KL, Fan AP. "Cortical oxygen extraction fraction using quantitative BOLD MRI and cerebral blood flow during vasodilation." Frontiers in Physiology 14 (2023): 1231793.
Lee QN, Chen JE, Wheeler GJ, Fan AP. Human Brain Mapping 44 (2023): 6537-6551.
Characterizing systemic physiological effects on the BOLD signal of resting-state fMRI in time-frequency space using wavelets
Using the Human Connectome Project, we showed that systemic physiology (heart rate variability and respiratory volume per time) correlates with functional MRI signals in brain networks. We leveraged wavelets to understand frequency-specific and dynamic nature of brain-body signaling. This information can inform our understanding of autonomic states and improve interpretation of physiological contributions to the BOLD signal.
- Wheeler GJ, Lee QN, Fan AP. "Dynamic Magnetic Resonance Vascular Fingerprinting During Hypercapnia for Quantitative and Multiparametric Cerebrovascular Reactivity Measures." Ann Int Conf IEEE Engineering in Medicine and Biology Society (2023): 1-4. doi: 10.1109/EMBC40787.2023.10339967
- Cogswell PM and Fan AP. "Multimodal Comparisons of QSM and PET in Neurodegeneration and Aging." Neuroimage (2023): 120068.
2022
- Zhao MY, Woodward A, Fan AP, Chen KT, Yu Y, Chen DY, Moseley ME, Zaharchuk G. "Reproducibility of cerebrovascular reactivity measurements: A systematic review of neuroimaging techniques." Journal of Cerebral Blood Flow and Metabolism 42 (2022): 700-717.
- Zhao MY, Fan AP, Chen DYT, Sokolska MJ, Ishii Y, Khalighi MM, Moseley M, Steinberg GK, Zaharchuk G. "Using arterial spin labeling to measure cerebrovascular reactivity in Moyamoya disease: Insights from simultaneous PET/MRI." Journal of Cerebal Blood Flow and Metabolism 42 (2022): 1493-1506.
2021
- Dolui S, Fan AP, Zhao MY, Nasrallah IM, Zaharchuk G, Detre JA. "Reliability of arterial spin labeling derived cerebral blood flow in periventricular white matter." Neuroimage: Reports 1.4 (2021): 100063.
- Zhao MY, Fan AP, Chen DYT, Sokolska MJ, Guo J, Ishii Y, Shin DD, Khalighi MM, Holley D, Halbert K, Otte A, Williams B, Rostami T, Park JH, Shen B, Zaharchuk G. Neuroimage 233 (2021): 117955.
Cerebrovascular reactivity measurements using simultaneous 15O-water PET and ASL MRI
Impacts of arterial transit time, labeling efficiency, and hematocrit
Multi-delay arterial spin labeling (ASL), which uses non-invasive MRI, showed good agreement with reference PET for brain blood flow during a vascular "stress test". Just as a cardiologist may have you run on a treadmill, a brain "stress test" uses a drug to dilate blood vessels in the brain to gauge its cerebrovascular reactivity.
We conclude that multi-delay ASL is the most appropriate non-contrast MRI technique to measure cerebrovascular reactivity - in response to a brain stress test - in healthy subjects.
- Fletcher E, DeCarli C, Fan AP, Knaack A. "Convolutional Neural Net Learning Can Achieve Production-Level Brain Segmentation in Structural Magnetic Resonance Imaging." Frontiers in Neuroscience 15 (2021): 745.
- Fan, Audrey P. "Editorial for: 'Decreased Spatial Variability of Individual Watershed Areas by Revascularization Therapy in Patients with High-Grade Carotid Artery Stenosis." Journal of Magnetic Resonance Imaging 54.6 (2021): 1890-1891.