PET for modeling brain tracer kinetics
Kinetic modeling of brain amyloid deposition with 18F-florbetaben provides a way to quantify binding density to amyloid plaques. We leverage the total-body EXPLORER PET/CT scanner to achieve dynamic acquisition of the full human body simultaneously. This permits noninvasive image-derived input functions (IDIFs) as an alternative to arterial blood sampling. Kinetic modeling also provides insight to rate parameters and perfusion that affect tracer dynamics over time.
![Amyloid](/sites/g/files/dgvnsk7901/files/media/images/option1.png)
We also use the total-body EXPLORER PET/CT scanner to estimate tau deposition based on 18F-PI-2620 tracer kinetics in brain regions known to be vulnerable in Alzheimer’s Disease.
![tau](/sites/g/files/dgvnsk7901/files/media/images/Kinetic_modeling.png)