Research

We develop advanced medical imaging technologies to study brain function and what goes wrong in stroke and dementia.

 

Our innovations include novel MRI (magnetic resonance imaging) and PET (positron emission tomography) scan acquisitions. We combine new scanning paradigms with biophysical models of brain tissue and image reconstructions to measure biomarkers that were previously not available.

The imaging biomarkers we investigate include cerebral blood flow, brain oxygenation, and cerebrovascular reactivity, the brain's response to a vessel "stress test". We also study the blood-brain barrier and its breakdown in neurological diseases, which alters how tracers and neuroinflammatory agents pass into the brain.

 

We seek to clinically translate our engineering discoveries, and are motivated by the need for imaging biomarkers to help patients with neurological and psychiatric disorders.


Projects