We investigate changes in white matter cerebral blood flow (CBF) and free water biomarkers surrounding white matter hyperintensities (WMH) in elderly participants and dementia patients.
Our imaging methods reveal that WMHs and adjacent layers have lower CBF than healthy white matter. CBF increases from tissue layers close to the WMH lesions, and recovers to normal levels further away from the lesion. The opposite trend was found with free water, indicating loss of white matter integrity close to the lesion.
We are also studying vascular contributions to functional networks as assessed by resting-state BOLD in patients from the Alzheimer's disease research center.